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About

Simon Lawrance, Ph.D

Department of Biology and Earth Science

Professor


Education

Yale University, PhD,1986
Earlham University, B.A, 1975

Research and Teaching Interests

  • Immunogenetics of the major histocompatibility gene complex
  • The role of integrin proteins in psoriasis, and the equine genome project.
Personal Bio
Simon teaches biology and genetics courses as well a Senior Year Experience service-learning class that travels to Africa each year. His Ph.D. dissertation focused on the molecular genetics of human histocompatibility genes complex and pioneered the application of pulsed field gel electrophoresis to human gene mapping. Following his Ph.D. studies, Simon undertook a postdoctoral fellowship at the Research Institute of Scripps Clinic in La Jolla, California in the laboratory of Dr. Per Peterson. At Scripps, Simon led a team that produced and studied transgenic mice expressing human MHC genes. Simon’s current research interests are an ongoing application of these studies on the human MHC. Variation in the MHC has long been known to be associated with a variety of autoimmune conditions. In collaboration with Dr. Chack Yang-Yu at Columbus’ Nationwide Children’s Hospital, Simon and his students are dissecting the association of copy number variation in the MHC with systemic lupus erythematosis.

/Contact

Science Building

SLawrance@otterbein.edu

614.823.1617